Both sides sit second and five points off the top in their respective leagues, but Spurs boss Mauricio Pochettino controversially opted to make seven changes to his team and paid the price in Germany.
Aubameyang headed in his 33rd goal in 38 appearances this season in the first half, before a clinical double from Reus after the break put Thomas Tuchel’s men in a dominant position.
Gonzalo Castro hit the post prior to Reus’ strikes in a match that could have been even worse for Spurs, who lacked any serious attacking threat without Harry Kane in the starting line-up and now know their continental hopes are all but over this season.
Spurs’ only attempt on target in the first half came in the opening minute, with Christian Eriksen’s long-range strike testing Roman Weidenfeller, one of two players to come into the hosts’ team.[Goal]